Make sure your minoxidil does not have any water in the ingredients. A multi-centre, double-blind, randomised, vehicle-controlled study for a quantitative estimation of hair re-growth in male subjects with androgenetic alopecia treated over 6 month with two ethanolic PSK 3841 solutions (2.5% and 5%). Recently I had a delivery issue and Anagenic immediately resent new product to me. 154992-24-2 Purity & Quality Control Other Androgen Receptor Products Darolutamide (ODM-201) New Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. We know that topically applied compounds can have systemic effects, and antiandrogens are somewhat indiscriminate in what they block. How To Use RU58841 RU58841 is available in liquid or powder form. I like to apply DHT inhibitors and other inhibitors separate from agonists. Evaluating the effectiveness of RU58841 will make us compare it to medications such as finasteride which inhibits or reduces the synthesis of DHT. RU58841 mixture tutorial , for educational purposes only.only to show how you make a mixture , author is for nothing responsibleMy new USA certified 99.6 %. Another reason K&B solution might be necessary for you to use is if you want to reconstitute your own RU58841 solutions but cant find Ethanol by itself (its not easy to find). I'm talking the hard bristles. While I understand it is stable for up to a year, I find when it comes from an older batch it is less effective. Subscribe and get my 20 Underground Bodybuilding Secrets You Wont Find On Google E-Book 100% FREE. You now have a bottle of Minoxidil with 50mg of RU58841 per ml of solution. We guarantee the safe arrival of your package. It works for saving your hairline, unlike dutasteride. Pull off the cap. Exfoliating Cream What is a 'Vehicle' It is an effort to improve information available to the users of /r/PEDs and will function as a type of skunkworks as we work on content and collaborate on research. Necessary cookies are absolutely essential for the website to function properly. Im excited to see what happens by the end of this bottle! Several medications are available for treating hair loss. I keep those sealed in several ziplock bags, in another closed container to ensure no water somehow seeps in and hits the powder. After we receive your order, we will ship your product within 24-48 business hours. You can buy this in group buys or elsewhere (Kane, MPB Treatments) and mix RU in that. Read More Creatine Causes Hair Loss. There was a study done back in 1998 on macaques, i don't know if this is really reliable. e.g. Very effective product. We provide full transparency on testing and all products are batch coded so that you can look up the test reports belonging to your batch. Slightly Overfilled to compensate for loss by adhesion. No portion of this page may be duplicated without consent. New Release (2016). Before starting treatment, I thought shedding was androgen induced. Bonnke Arunga is a senior medical student and an expert health writer. Ordered multiple times and only had an issue once with damaged shipment. You should realize that RU58841 is not an FDA-approved medication thus you must stay cautious about the usage of this product. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Voila. Privacy Policy. However if you wish to make your own solution without the minoxidil, you can use ethanol to do so. There you have it, now you have a 50ml 5% RU58841 K&B solution dosed at 50mg/ml. If it does, and you mix it with RU then the RU will not work. RU58841 is a specific androgen receptor antagonist or a so called anti-androgen. This is the real deal. AMAZING PRODUCT, GREAT SERVICE. Even at high doses of up to 0.01 milligrams, the action was still limited to the site of application a much-desired relief for the researchers. By clicking Accept, you consent to the use of ALL the cookies. ), from Maseno University. Thank you for your perfect informative post. Is it okay to mix into 60ml minoxidil. It seems that the combo hits things from different angles to . Add to Favorites . A lot has transpired since the inception of the idea. This article is intended for educational / informational purposes only. Hair fibers are products that are specifically meant for those people who are suffering from hair loss. Have recommended your Company to 3 friends and ALL are very happy with outcome. 0.001g Scale (roughly $30.00) 8. (like when it's shipped or caught in customs) Also, 1% RU from MPB treatments isn't enough RU, file poly kalo apotelesma , prepei na eisai paenytyxhs, sygxarhthria. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. The concept of RU58841 is quite old. The next procedure depends on whether you are using other hair treatments as well. Be careful that it does not trickle down onto the forehead, sides of the face, and neck. 3. However, the fact remains that it is not recognized or regulated by the FDA. It may not display this or other websites correctly. In this guide I show and explain how to use RU with Everclear. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Now I am 52y.old and on the Norwood Hamilton Scale I am barely a 2. Written by Kartik Kumar Rathi Updated On February 1, 2023 Compound Summary Class of Compound Peptide (NSAA)/SARMs Mechanism of Action However, as there have been no direct human studies for more than a decade, the FDA has not approved it for the management of any condition. To apply minoxidil topical foam: Open the container by matching the arrow on can ring with the arrow on cap. These are the only companies I currently use for my own personal research: Anageninc, Chemyo. Cloneville 2 yr. ago https://www.chemyo.com/ru58841/ Id just stick with this yamanstoday 2 yr. ago Dosing at 2ml (100mg), I get a pretty high heart rate for about an hour. Thanks anagen. Copyright 2022 More Plates More Dates All Rights Reserved. PLEASE FAMILIARIZE YOURSELF WITH OUR TERMS AND CONDITIONS PRIOR TO ORDERING. My only complaint and reason for 4 stars, is that the batch date is sometimes well past 6+ Months, sometimes ranging to a Year. As a result, you may want to apply it about 20-30 minutes after taking a shower. With the raw powder you can mix your own concentration precisely and you make or use your own "vehicle". If you are one of those whos scalp is irritated by the Propylene Glycol in the traditional standard RU58841 carrier blend, this will be a quick instructional guide for you specifically detailing how to mix a RU58841 solution in K&B Solution. RU58841 is a non-steroidal experimental anti-androgen, which is intended for use as a topical treatment for acne and androgenic alopecia (male pattern baldness). Audio mixing is the process of taking recorded tracks and blending them together. For a better experience, please enable JavaScript in your browser before proceeding. Once you have made up your mind, choose the 99% pure grade while taking care to read the label carefully so that nothing is appearing out of place. See this article for more information: https://www.propublica.org/article/the-myth-of-drug-expiration-dates. However, there is a lot of misinformation floating around on the internet about the use and side effects of DHT blockers and many unsubstantiated claims about its alternatives. There is also another popular one (as mentioned previously) called KB. Been using it for 9 months. This is the only solution for hair loss period. If you dont already know what RU58841 is, it is a non-steroidal experimental anti-androgen, which is intended for use as a topical treatment for acne and androgenic alopecia (male pattern baldness). VitaminP. Once youve done that, you can turn off the scale and put it away. Ive only been using for 2 weeks so cant provide a 5 star rating, yet. Re-grew all my hair couldnt be happier. Most of the purchases for RU58841 can be made online from several of the most popular suppliers like Chemyo, Kane, andAnagen Inc. Suggestions? As opposed to pre-mixed RU58841 solutions, all RU58841 raw powder (unmixed) should always be kept in the freezer. This makes vendors mess around with the concentration and purity of the product. Therefore androgens dont have the chance to bind and start the chain reaction of androgenetic alopecia and begin the so called miniaturization process. It is important to store RU58841 in a dry, dark, and cool place as it degrades in heat and sunlight. Creatine Causes Hair Loss. Upload your video This non steroidal topical androgen antagonist was investigated for therapeutic value in androgenetic alopecia and acne. If you need to make 8% RU, you need to add 4.8 grams of RU. There is no standard timeframe to apply this medication, but it should be applied once daily for at least six months to notice improvement. It prevents miniaturization by blocking DHT, Testosterone, and other androgens from attaching to the hair follicle. (1997). You should now have a cloudy solution of RU58841. 6 Best Hair Fibers to Effortlessly Conceal Your Hair Loss. Step 1: Get 99%+ plus RU58841 ( Current batch is from https://www.chemyo.com/ru58841.html but other sources are fine too ) Step 2: Measure 3 Grams RU58841 Step 3: Shake 1-5 minutes until the. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. RU58841 is a bit watery so it is best to apply within and behind the hairline. Small bottles 6. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase. US orders above $100 and International orders above $250 Qualify for free discreet shipping. Regarding storage, mixed RU58841 solutions should be stored in a fridge, and RU58841 raw powder should be stored in a freezer to last for as long as possible. Add 2.5 grams of powder to the empty beaker on the scale until you see the scale reading 2.5 grams. But based on the physiologic processes it undergoes, we can hypothesize on some of its potential side effects. If I see any new hairs I will increase my rating. Step 3: Shake and swirl the solution lightly until the RU58841 powder has completely dissolved inside the bottle, and the solution is completely clear. RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA). RU58841 is a nonsteroidal anti-androgen for hair loss (androgenic alopecia). Only issue I see is lack of safety studies, specially long term. Could be in my head, but would be nice if the batches were atleast from the past 3-6 months. After you have applied it, let it dry for about a minute. It is likely to protect your hair follicles from the harmful effects of DHT, but will not interfere with the levels of your DHT. Take, for instance, a little drug called RU58841. Follicular regrowth with 5 -reductase inhibitor (finasteride) or androgen receptor blocker (RU58841) in the bald scalp of the stumptailed macaque. Excellent customer service from Anagen. Add the products you need to your cart. RU58841 Batch RU1007 RU58841PG8 Concentration Audit, RU58841 Batch RU1008 RU58841PG5 Concentration Audit, RU58841 Batch RU1009 RU58841KB5 Concentration Audit, RU58841 Batch RU1010 RU58841PG5 Concentration Audit, RU58841 Batch RU1010 RU58841KB5 Concentration Audit, RU58841 Batch RU1011 RU58841PG5 Concentration Audit, RU58841 Batch RU1011 (Retest) RU58841PG5 Concentration Audit, RU58841 Batch RU1011-2 RU58841PG5 Concentration Audit, RU58841 Batch RU1011 RU58841KB5 Concentration Audit, RU58841 Batch RU1014 RU58841PG5 Concentration Audit. Shipping is always incredibly fast, solid product! I will be using RU for the rest of my life unless something better gets invented. https://www.gofundme.com/hair-congress-2017, https://www.ncbi.nlm.nih.gov/pubmed/9798729, Shiseido to Begin Cell Hair Regeneration Trial, Kyocera to Begin Regenerative Hair Loss Treatment Research. RU58841 (also known as PSK-3841 or HMR-3841) is a non-steroidal anti-androgen with potency (IC50 = 100 nM, Ka = 1.1 nM) which was previously investigated for use as a topical treatment for acne, androgenetic alopecia, and hirsutism. If you already use Minoxidil liquid every day, you want to use RU58841, and your dose has consistently proved to be constant between the two compounds, you may be in the ideal position to use your Minoxidil liquid as your mixing solution for RU58841. DOI: Battmann, T., Bonfils, A., Branche, C., Humbert, J., Goubet, F., Teutsch, G., & Philibert, D. (1994). and our Otherwise, the hairs in that region will also grow thicker over a period of time. Step 1: Measure out 3000mg (3 grams) of RU58841 raw powder per bottle of Minoxidil by weighing it out. If possible, consult your doctor or healthcare provider before you use this product, or when you notice symptoms after using it. Very quick and super effective. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Wanna Be Loser. IE; RU, SETI, etc. We strive to achieve absolute first class customer service as well as extremely high quality products! These cookies do not store any personal information. You are using an out of date browser. I will caveat that per my RU58841 write-up, I don't recommend any DHT blocking/targeting/reducing compound unless also using exogenous test. All the benefits of DHT are left intact when you use RU58841. First is cheaper, second is more straightforward. Once you press this, it will reset the scale to 0 even with the beaker on it. All that is required with the K&B solution is to pour your desired amount of RU58841 powder into the premixed K&B solution, then shake or stir lightly until it is thoroughly dissolved and mixed evenly. 5) Buy yourself a small measuring spoon, just get something cheap but SMALLeven from a cheap 'Dollar Store'. There are a lot of myths surrounding the proper storage of this research chemical, and Im going to quickly clarify every thing for you in this quick article. As opposed to pre-mixed RU58841 solutions, all RU58841 raw powder (unmixed) should always be kept in the freezer. RU58841 Recommendations Or Dosing Guidelines The things you'll need: RU sample At the same time order off of eBay or Amazon a 0.001 gram digital scale. This can only be done when RU is mixed into a solution like Everclear or KB and dissolved completely. Mixing RU58841 5% solution - The easy way! Updated: 25 Mar 2023 11:22 am. It has been found to be well tolerated by the people using it, and not many side effects have been reported. What is more, you dont have to worry about side effects such as erectile dysfunction, which is relatively common with finasteride. Unfortunately, I doubt we will ever know it, Blocking 5a-reductase to tackle hair loss is like killing a fly with a bazooka. The mere fact that the effect of RU58841 does not interfere with the synthesis of DHT and testosterone, makes it a very promising drug. It's also still cold enough to offset degradation to a large degree, but not cold enough to cause crystallization of the powder in the solution basically. Subscribe and get my 20 Underground Bodybuilding Secrets You Wont Find On Google E-Book 100% FREE, There are advantages and disadvantages to mixing your RU58841 with Minoxidil liquid, What You Will Need To Mix Your Own RU58841 And Minoxidil Combination Solutions, Adding The RU58841 Powder To The Minoxidil Liquid Solution, Cheaper if you already use Minoxidil liquid every day, Efficient as Minoxidil already comes in separate 60 ml bottles (very close to the standard 50ml PG + Ethanol solutions we use to measure and mix our RU58841, Requires that you use Minoxidil every single time you apply RU58841 because they are mixed. A daily dose of 50 mg applied in areas that are affected by alopecia will usually suffice. It is available as a pre-made solution or raw powder. So you have to apply it carefully on the scalp, behind the hairline, and spread it to cover the target area. Read More 6 Best Hair Fibers to Effortlessly Conceal Your Hair LossContinue, The Food and Drug Administration approved the use of finasteride in 1997 for, Read More Topical Finasteride for Hair Loss: Better than Oral?Continue, In August 2011, a cosmeceutical company Divine Skin Inc., released a new molecule to, Read More Nanoxidil for Hair Loss: Efficacy, Side-Effects, vs. MinoxidilContinue. Been wondering if there's some composition or form of RU or something to mix it with to make your scalp respond or something. Prostraken decided to conduct a phase 3 trial as well, but this never went ahead. Minoxidil is an antihypertensive vasodilator medication. I don't like the fact that it has to be used or frozen so if someone has a better recipe please share or link RU58841 Recommendations Or Dosing Guidelines The things you'll need: At the same time order off of eBay or Amazon a 0.001 gram digital scale. In studies and clinical trials RU58841 has shown to; Strongly compete against DHT Increase cellular replication rate in the matrix cells They act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT). Thank you for taking the time to make this, that is THE question . As a result, the systemic side effects that occur due to lowered production of DHT are not seen, for example, sexual side effects. Do not apply it on raw skin. Next, pour the 50ml of K&B solution into the beaker with the 2.5 grams of RU58841 raw powder. A controlled study of the effects of RU58841, a nonsteroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosteroneconditioned nude mice. Great service, shipped immediately. Using 5% for a few years. 3) Buy yourself the following items at the drug store; -1ml dropper -100ml or more of propylene glycol (aka PG) -Everclear alcohol. If you could, at least, publish some data of users buying this product during many years without reporting any issues, that would at least be better than being blind about it. Significantly less shedding and obvious hair growth. Been wondering if there's some composition or form of RU or something to mix it with to make your scalp respond or something. Great, quality product and excellent delivery. 2% Formulation. This non steroidal topical androgen antagonist was investigated for therapeutic value in androgenetic alopecia and acne. I had two very noticeable bald patches forming after 6 months of TRT and within about 6 weeks of daily application of RU58841 it all re-grew back like nothing happened. Read our advertising policy. It's not bad, minoxidil has all the solvents needed to dilute the RU powder and has shown no interaction with RU so far. Dries out faster in my opinion, so you might wanna check that out also. It will keep your scale looking like new and protect it from scratches, bumps, and everyday wear and tear. RU58841 (roughly $100 per 10g) 2. RU powder cannot be applied directly on the scalp with the hopes of being effective. With Best Regards, Since this medication is anti-androgen, it may be able to target androgen-dependent skin conditions such as acne and androgenic alopecia. I know it's the Tretinoin because I've been spot testing. This is where RU58841 works differently. Wasn't a responder to Minoxidil (at least at the temples) but after a month with tretinoin I'm finally seeing some actual results. Offline. For the carrier (what the RU58841 raw powder is mixed in), I prefer PG (propylene glycol) + Ethanol. You can also reach the Admin of the site on the Forums at username Admin fairly quickly. The crucial part is knowing how to store this medication and how to use it. Alternatively, you can purchase the pre-made version from Chemyo. Many claimed that this "magic pill" has helped grow back stubborn hairs in areas considered irreversibly damaged. I have been researching the product for 3 years with good maintenance research results. Do you have any pictures of your hair from using this stuff. If you choose instead to add the RU direct into the Minoxidil, do it slowly and carefully (no shit). It is also known as PSK-3841 . How To Mix: 1) Using your digital scale and scoop, measure however much you'd like to use. If You Have A Very Hard Time Finding Ethanol. The products we offer are intended for . RU58841 | RU-58841 Solution 50mg/ml - 50ml. I typically wait a couple of minutes for it to mix in completely. Dear AnagenInc. (There was a picture in the pdf that they sent me. So, it actually blocks DHT from attaching itself to the receptors. DHT blockers (oral) are one of the few treatments for androgenetic alopecia (male and female pattern hair loss) that is approved by the FDA. RU58841 is a specific androgen receptor antagonist or a so called anti-androgen. Truth or Myth?Continue. Eventually, one company ProStraken acquired the full rights to RU58841 and changed its name to PSK3841. Then simply apply the solution to the scalp and that's pretty much it. It just works. Very pleased with their customer service! This has stopped my hair loss and allow for regrowth. /r/tressless , 2023-03-16, 12:16:40 Once its crystal clear your solution is ready to go, and you can get your funnel and 50ml+ K&B container and pour the solution through the funnel back into the empty bottle you have to store your solution in. Though like any other RU58841 product, it is not FDA regulated. In general, most apply RU58841 as a topical agent (directly to the scalp) or digest it orally through a powder substance. Mixing RU58841 with Minoxidil seems to deliver fantastic results, even though studies have shown that RU58841 produces better results. Hopefully this helps the noobies as well as some small tricks for old timers. Have not used product long enough but the team here were very helpful and send me an additional order for free when package looked like it had been tampered with, Fast delivery too early to review product, easy to work with, will continue business. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. ProStrakan rebrands as Kyowa Kirin. Less than 100mg I'm safe from sides. A few monkey-based studies have been done, which determined the optimal dosing of RU58841 to be 5%, and one study compared it against finasteride. ''I have hope for life man'' - buckthorn, 2018. Like finasteride, the stuff works by interfering with the body's production and uptake of DHT, but with a significantly shorter half life. We have actually verified this by doing an HPLC stability test that showed that there was no significant degradation after 24 months at room temperature. Get New Research, Treatments, and Discoveries Delivered to your Inbox. The Ru58841 does what its supposed to do, way less oily surface on the research subject. It does if you use enough solution for the amount of RU powder you're reconstituting, as well as shake/stir it good enough. It is actually quite simple how to mix the two, and it simply involves some basic math. Been using 3 weeks on test subject. The costumer service was awesome and they are really available for any further questions. You will need the following at a minimum: Step 1: Measure out 3000mg (3 grams) of RU58841 raw powder per bottle of Minoxidil by weighing it out. I will use RU58841daily for life now. Users Before and After results 5% RU58841 Topical How to Mix guide: http://www.baldtruthtalk.com/showthread.php?t=12391Trusted Sources selling RU58841:http:. Here is the reason: RU58841 competitively binds to the receptors of DHT. Makes small dosing changes near impossible because if you want to alter your RU58841 dosage, then you will also be forced to alter your Minoxidil dosage, which could lead to unwanted side effects. So I've been on RU58841 since late November and I don't think it's helped my hairline out. A list of side effects would be useful. As previously mentioned, initial trials on this medication revealed that it is very potent even at low doses. This field is for validation purposes and should be left unchanged. The pre-made solution comes in a concentration of 5% RU58841, at a dose of 50 mg/ml. The results are very encouraging which shows that the current anageninc route of synthesis is stable for at least 24 months at room temperature. Ive been ordering from Anagen for 2 years. Right now, you are probably aware that hair loss occurs due to the action of DHT on the hair follicles. I am beyond pleased with this product and will recommend to anyone experience hair loss. This combination is pretty common, since many folks are using both, especially on cycle. RU58841 5% solution. Place your beaker/cup bottle on top of the scale, measure out your 3 grams of RU58841 and place it inside. Karma: 187. Actually, even small doses as low as 0.001 milligrams showed significant local effects. Privacy Policy. It blocks androgens from binding, such as DHT. Uno, H., Ye, F., Imamura, K., Obana, N., & Bonfils, A. After dedicating over 8 years to extreme self-improvement, I have created "More Plates More Dates" as a one stop shop for helping you to get yourself on the right path to the "best you" possible too. This is a quick write-up on how to make your own Minoxidil / RU58841 formula, prompted by a question from u/PopBottlesPopHollows.

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